Aptevo Therapeutics announced compelling early results from the ongoing RAINIER Phase 1b/2 trial evaluating mipletamig as a frontline therapy for Acute Myeloid Leukemia (AML). The first patient dosed in this trial achieved a 90% reduction in leukemic blasts within the initial 30 days of treatment. This significant reduction indicates rapid and potent anti-leukemic activity.
Mipletamig is being evaluated in combination with standard-of-care venetoclax and azacitidine for AML patients. The observed efficacy trend in the RAINIER trial continues the positive results seen in prior mipletamig AML studies, reinforcing the drug's potential. This consistency in early data is crucial for advancing the clinical program.
The company's decision to evaluate mipletamig as a frontline combination therapy was based on favorable data from earlier trials, which demonstrated strong safety, efficacy, and tolerability profiles. The current results further support mipletamig's potential to redefine treatment paradigms for AML patients.
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