AstraZeneca and Hong Kong‑listed Jacobio Pharma announced a global exclusive license for Jacobio’s proprietary pan‑KRAS inhibitor JAB‑23E73. Under the agreement, AstraZeneca will hold exclusive development and commercialization rights outside China, while the two companies will jointly develop and commercialize the drug within China.
The deal provides Jacobio with an upfront payment of $100 million and up to $1.915 billion in milestone payments, plus tiered royalties on net sales outside China. The total potential value of the transaction is $2.015 billion, underscoring AstraZeneca’s confidence in the candidate’s therapeutic and commercial prospects.
JAB‑23E73 targets multiple KRAS mutation subtypes, addressing a critical unmet need in solid tumors. KRAS is the most frequently mutated oncogene, present in roughly 23% of all cancer patients. By adding a pan‑KRAS inhibitor to its portfolio, AstraZeneca strengthens its position against competitors such as Amgen, Mirati (now Bristol Myers Squibb), Pfizer, Lilly, and Roche, and expands its reach in the high‑growth KRAS‑targeted market.
Jacobio benefits from the upfront cash and the potential for substantial milestone payments, validating its induced allosteric drug‑discovery platform and providing resources to advance other pipeline programs. Investors reacted by selling shares, with Jacobio’s Hong Kong listing falling 14% on the first trading day after the announcement, reflecting concerns that the $100 million upfront may undervalue the licensing rights despite the deal’s long‑term upside.
Matt Hellmann, Senior Vice President of Early Oncology and Precision Medicine at AstraZeneca, said, “KRAS is one of the most important oncogenes in cancer, and JAB‑23E73 offers a novel approach to address the unmet need in pancreatic, colorectal and lung cancers.” Yinxiang Wang, Chairman and Co‑CEO of Jacobio, added, “Partnering with AstraZeneca marks a significant step forward, bringing our world‑class programs to the global stage and maximizing the value of our R&D innovation.”
The agreement aligns with AstraZeneca’s broader oncology strategy, which emphasizes global expansion and deepening its presence in China. Jacobio’s platform, based on induced allosteric discovery, has already produced JAB‑23E73 and other KRAS‑targeted candidates, positioning the company to capitalize on the rapidly growing KRAS inhibitor market.”],
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