BriaCell Therapeutics Corp. (NASDAQ: BCTX) announced a new research collaboration with Receptor.AI, a company that specializes in AI‑driven drug discovery. The partnership, which began on November 20, 2025, will focus on designing isoform‑selective kinase inhibitors for multiple cancer indications, combining Receptor.AI’s AI‑enabled molecular design platform with BriaPro’s proprietary technology to speed the development of selective kinase inhibitors that could enhance immune‑mediated tumor targeting.
The collaboration marks a strategic expansion for BriaCell beyond its core cell‑based immunotherapy platforms, Bria‑IMT and Bria‑OTS. By adding a small‑molecule discovery arm, BriaCell aims to broaden its oncology portfolio and create complementary therapies that can be combined with its existing immunotherapies. This move positions the company to leverage AI‑driven design to address the challenging problem of isoform selectivity, a key hurdle in kinase inhibitor development that has limited the success of many small‑molecule oncology drugs.
Receptor.AI’s platform uses machine learning to predict binding affinity, selectivity, and ADMET properties, allowing the rapid generation of candidate molecules that target specific kinase isoforms. BriaCell’s expertise in immune‑cell engineering and Receptor.AI’s computational power together create a pipeline that can move from in‑silico design to preclinical testing faster than traditional discovery routes, potentially shortening the time to clinical development and reducing early‑stage attrition.
The partnership is expected to accelerate BriaPro’s pipeline of next‑generation kinase inhibitors and open new therapeutic avenues for BriaCell’s oncology programs. By combining selective kinase inhibition with cell‑based immunotherapy, the company could develop combination regimens that improve efficacy and reduce toxicity, addressing unmet needs in cancers that are resistant to current treatments.
"This partnership marks an important step in BriaCell’s strategic expansion beyond cell‑based immunotherapy into small‑molecule discovery, reinforcing our mission to deliver differentiated and complementary approaches to cancer treatment," said Dr. William V. Williams, President and CEO of BriaCell and BriaPro. "Receptor.AI’s AI‑first molecular design and rigorous ADMET constraints will enhance precision and translational confidence from the earliest stages of discovery," added Dr. Alan Nafiev, CEO and Founder of Receptor.AI.
The collaboration underscores BriaCell’s commitment to innovation across multiple modalities and positions the company to capture a larger share of the oncology market. While the partnership introduces new research and development costs, the potential for high‑margin combination therapies and accelerated pipeline progression could offset these investments and drive long‑term shareholder value.
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