CAMP4 Therapeutics announced a strategic research, collaboration and license agreement with GlaxoSmithKline (GSK) that provides a $17.5 million cash upfront payment and the opportunity to earn up to $440 million in milestone payments and tiered royalties on future product sales.
The deal leverages CAMP4’s proprietary RAP Platform® to identify antisense oligonucleotide (ASO) candidates that upregulate gene expression for neurodegenerative and kidney disease targets. GSK will assume responsibility for further development and commercialization of any candidates that emerge from the collaboration, allowing CAMP4 to focus on discovery while benefiting from GSK’s extensive development, manufacturing and commercialization expertise.
The upfront payment extends CAMP4’s working‑capital runway beyond 2027, giving the company additional time to advance its preclinical pipeline. The potential milestone structure represents a long‑term revenue opportunity that could significantly increase the company’s valuation if the ASO candidates reach market approval.
CAMP4’s CEO, Josh Mandel‑Brehm, said the partnership “underscores the potential of our discovery platform to create transformational medicines for patients.” GSK’s SVP of Research Technologies, Chris Austin, added that the agreement “demonstrates our approach of harnessing cutting‑edge technologies to deliver transformational therapies for patients.”
The collaboration follows CAMP4’s October 2024 IPO and a $30 million stock offering announced on the same day as the GSK deal. The company’s liquidity position, with more cash than debt, provides flexibility to invest in its pipeline while the partnership mitigates late‑stage development risk by transferring those responsibilities to GSK.
The partnership validates CAMP4’s RAP Platform® and positions the company within the growing RNA‑based therapeutics market, where ASO therapies are gaining traction for conditions such as Alzheimer’s, Parkinson’s and chronic kidney disease. GSK’s expanding RNA portfolio, including prior deals with Empirico and Rgenta Therapeutics, aligns with its strategy to leverage innovative technologies for drug discovery.
The deal is a material event for CAMP4, as it provides both immediate capital and a potential multi‑hundred‑million‑dollar revenue stream, while also enhancing the company’s credibility and accelerating its path to market for ASO therapeutics.
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