Geron Corporation announced a comprehensive restructuring plan that will cut its workforce by roughly one‑third, eliminating about 86 employees from a total workforce of 260. The company expects the restructuring to be substantially complete in the first quarter of 2026 and to lower 2026 operating expenses below 2025 levels, with savings beginning in the first quarter of 2026.
The restructuring is designed to free resources for the U.S. commercialization of RYTELO, Geron’s telomerase inhibitor approved for lower‑risk myelodysplastic syndromes, and to support the Phase 3 IMpactMF trial in relapsed/refractory myelofibrosis. Management highlighted that the plan will sharpen the U.S. sales strategy, prioritize clinical development, and improve financial discipline without additional financing.
RYTELO’s recent performance has been a key driver of the restructuring. In Q3 2025, the drug generated $47.2 million in revenue, falling short of the $54.49 million consensus estimate and marking a 3 % quarter‑over‑quarter decline in demand. The revenue miss, combined with competitive pressure from Bristol Myers Squibb’s luspatercept, has prompted Geron to accelerate cost controls and focus on high‑margin growth.
The company’s cash position as of September 30, 2025 stood at $421.5 million, down from $502.9 million at the end of 2024. Despite the cash reserve, Geron has been operating at a net loss, and the restructuring aims to bring operating expenses below the $250‑$260 million range projected for fiscal 2025.
Management emphasized that the restructuring will not impede the IMpactMF trial, which is progressing with 75 % enrollment as of December 2024. The trial’s interim analysis is now expected in early 2026, with a final analysis projected for early 2027.
Geron will disclose detailed restructuring charges in a forthcoming Form 8‑K filing. The company’s CEO, Harout Semerjian, stated that the restructuring is being implemented “from a position of strength and in the spirit of prudent fiscal management” and that the company remains focused on driving RYTELO growth, exploring international opportunities, and advancing the IMpactMF trial.
The announcement reflects Geron’s strategy to achieve profitability without additional financing, relying on disciplined cost management and accelerated commercialization of its core product while maintaining a robust clinical pipeline.
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