HCW Biologics Inc. reported positive results from an investigative study of its proprietary second-generation T-cell engager program in non-human primates. The study demonstrated safe dose levels of its lead drug candidate, which were well tolerated at levels significantly higher than the identified efficacious dose level.
This program has successfully addressed key challenges associated with first-generation T-cell engagers, including manufacturability, preclinical safety profile, and the ability to treat a wide spectrum of solid tumors. These advancements are crucial for the further development of the therapy.
The positive results from these non-human primate studies position the program for a potential high-value corporate partnership. This de-risks the program and enhances its attractiveness for external collaboration and investment.
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