Illumina announced a strategic investment in MyOme, a clinical whole‑genome analysis platform, to support the company’s Proactive Health (MPH) trial. The trial will enroll patients in 2026 and combine Illumina’s next‑generation sequencing (NGS) technology with MyOme’s AI‑integrated risk models to assess early detection and prevention of chronic conditions, cancers, and rare diseases.
The partnership gives Illumina a direct role in a real‑world clinical study that could demonstrate cost savings of more than $200 billion per year for the U.S. healthcare system. By providing sequencing capacity and data‑analysis expertise, Illumina aims to generate evidence that proves the economic value of whole‑genome sequencing (WGS)–based preventive care and to expand its presence in the growing precision‑medicine market.
Illumina’s revenue for the most recent twelve months was $4.29 billion, with a gross profit margin of 68.38%. Q3 2025 revenue was $1.08 billion, flat versus Q3 2024, while Q4 2024 revenue rose 1% to $1.10 billion. The flat Q3 result reflects a mix shift toward higher‑margin consumables and a slowdown in instrument sales, while the modest Q4 increase is driven by a rebound in consumable demand and a small uptick in service revenue.
MyOme’s platform analyzes over 150 genes with actionable findings and integrates polygenic risk scores. The MPH trial will enroll patients in 2026, and the partnership positions Illumina to capture a share of the projected multi‑billion‑dollar AI‑driven genomic risk‑assessment market. Illumina’s investment signals a strategic shift beyond its traditional sequencing‑instrument and consumables business toward clinical genomics and population‑health initiatives.
Jakob Wedel, Illumina’s Chief Strategy and Corporate Development Officer, said the collaboration “represents an important evolution in the use of genomics for preventive care. By combining Illumina’s sequencing technology with MyOme’s AI‑integrated risk models, we are helping advance science and generate the clinical evidence needed to transform how diseases are detected and managed.”
The partnership also leverages Illumina’s installed base to accelerate adoption of WGS in clinical practice, strengthening its recurring revenue stream from consumables and positioning the company for long‑term growth in the precision‑medicine space.
The investment does not disclose specific financial terms, but the strategic nature of the deal underscores Illumina’s commitment to expanding its clinical portfolio and to generating evidence that can unlock new revenue streams in preventive care.
The collaboration is expected to provide a robust evidence base that could support reimbursement models for WGS, potentially opening new markets for Illumina’s sequencing instruments and consumables while reinforcing its position as a leader in clinical genomics.
The partnership reflects Illumina’s broader strategy to integrate AI and data analytics into its sequencing platform, a move that aligns with industry trends toward precision medicine and population health. By embedding its technology in a large‑scale, real‑world trial, Illumina can demonstrate the clinical and economic value of WGS, a key driver of future growth in the genomics market.
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