Merck announced on January 30, 2025, its decision to stop a late-stage study of its Winrevair treatment for pulmonary arterial hypertension (PAH) ahead of time. This action was based on strong efficacy shown in previous studies and a review of the totality of data from the Winrevair clinical program.
The Phase 3 'Hyperion' study, which was evaluating Winrevair versus placebo in recently diagnosed adults with PAH, lost clinical equipoise, meaning it was deemed unethical to continue providing patients with the inferior therapy. This allows all study participants to access the drug.
This early halt underscores the exceptionally strong benefits demonstrated by Winrevair, a key drug from Merck's $11.5 billion acquisition of Acceleron Pharma. It reinforces Winrevair's potential as a major growth driver and a transformative treatment for this rare, progressive, and life-threatening blood vessel disorder.
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