Pfizer announced on April 15, 2025, its decision to discontinue the development of danuglipron, an oral glucagon-like peptide-1 (GLP-1) receptor agonist, for chronic weight management. The discontinuation was attributed to safety concerns, including a study participant developing potential drug-induced liver injury.
Danuglipron was an investigational oral therapy that aimed to compete in the rapidly expanding obesity drug market. Pfizer's decision to scrap this program removes a significant competitor from the oral GLP-1 space. This development highlights the challenges associated with developing oral formulations of these potent weight-loss drugs, particularly regarding safety and tolerability profiles.
For other companies developing oral obesity treatments, such as Viking Therapeutics with its VK2735 oral tablet, Pfizer's exit from this specific program is a positive development. It potentially reduces competitive pressure and underscores the importance of a robust safety and tolerability profile for market success in this therapeutic area.
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