Zymeworks Inc. announced on May 19, 2025, the presentation of new preclinical data for ZW1528, a novel IL-4Rα x IL-33 bispecific molecule, at the American Thoracic Society (ATS) International Conference. ZW1528 is designed to address respiratory inflammation, such as mixed-type chronic obstructive pulmonary disease (COPD), by inhibiting multiple pathways.
The key findings demonstrated that ZW1528 binds with high affinity to both IL-4Rα and IL-33, driving potent blockade of two distinct signaling axes implicated in inflammatory disease. Preclinical studies showed superior blockade of cytokine-driven activation compared to monoclonal antibodies targeting single pathways, indicating potential for broader and more durable disease control.
This presentation highlights Zymeworks' strategic expansion into autoimmune and inflammatory diseases, leveraging its expertise in multispecific antibodies. The company plans a non-U.S. regulatory filing for Phase 1 clinical studies for ZW1528 in the second half of 2026, further advancing its diversified R&D strategy.
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