Zymeworks Inc. hosted its Research & Development Day on December 12, 2024, providing updates on its oncology programs and announcing strategic expansion into autoimmune and inflammatory diseases (AIID). The company reported being on track to deliver five Investigational New Drug (IND) applications as part of its '5 by 5' solid tumor strategy, approximately 18 months ahead of its original target timelines.
A key highlight was the nomination of ZW209, a novel trispecific T cell engager, as the fifth development candidate in Zymeworks' solid tumor portfolio. This advancement underscores the company's commitment to developing next-generation multifunctional biotherapeutics for difficult-to-treat cancers.
Furthermore, Zymeworks announced its expansion into AIID and hematology oncology, leveraging its clinically validated Azymetric™ technology platform. The company introduced ZW1528, a novel IL-4Rα x IL-33 bispecific molecule, as its first development candidate in AIID, signaling a diversification of its therapeutic focus beyond oncology.
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